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市场调查报告书

寡核苷酸合成的全球市场:2020年~2027年

Global Oligonucleotide Synthesis Market - 2021-2028

出版商 DataM Intelligence 商品编码 961168
出版日期 内容资讯 英文 180 Pages
商品交期: 约2个工作天内
价格
寡核苷酸合成的全球市场:2020年~2027年 Global Oligonucleotide Synthesis Market - 2021-2028
出版日期: 2021年07月15日内容资讯: 英文 180 Pages
简介

寡核苷酸合成,是具有确定化学结构的较短核酸片段的化学合成。这个手法,由于提供对目的排列的客制化的寡核苷酸的迅速且廉价的存取,非常有助于在目前研究室的使用。制药、生物科技部门的研究活动增加与创新的诊断、治疗技术的需求高涨,使市场成长。

本报告提供全球寡核苷酸合成市场相关调查分析,产业分析,各市场区隔的市场分析,竞争情形,主要企业等相关的系统性资讯。

目录

第1章 全球寡核苷酸合成市场:调查手法和范围

第2章 全球寡核苷酸合成市场:市场定义和概要

第3章 全球寡核苷酸合成市场:摘要整理

第4章 全球寡核苷酸合成市场:市场动态

  • 影响市场的要素
    • 促进因素
    • 阻碍因素
    • 机会
    • 影响分析

第5章 全球寡核苷酸合成市场:产业分析

  • 波特的五力分析
  • 供应链分析
  • 临床试验
  • 价格分析
  • 法规分析
  • 偿付分析
  • 未满足需求

第6章 全球寡核苷酸合成市场:COVID-19分析

  • 对市场的COVID-19分析
  • 在COVID-19中的价格趋势
  • 供需频谱
  • 大流行时的市场相关的政府举措
  • 制造商策略性举措
  • 结论

第7章 全球寡核苷酸合成市场:各产品

  • 简介
  • 市场规模分析、与前一年同期比较成长分析:各产品区隔
  • 市场魅力指数:各产品区隔
    • 试剂
    • 设备
    • 合成寡核苷酸

第8章 全球寡核苷酸合成市场:各用途

  • 简介
  • 市场规模分析、与前一年同期比较成长分析:各用途
  • 市场魅力指数:各用途市场区隔
    • 研究
    • 诊断
    • 治疗

第9章 全球寡核苷酸合成市场:各终端用户

  • 简介
  • 市场规模分析、与前一年同期比较成长分析:各终端用户
  • 市场魅力指数:各终端用户市场区隔
    • 医院
    • 学术、研究机关
    • 制药、生物科技企业
    • 临床检验室

第10章 全球寡核苷酸合成市场:各地区

  • 简介
  • 市场规模分析、与前一年同期比较成长分析:各地区
  • 市场魅力指数:各地区
  • 北美
  • 欧洲
  • 南美
  • 亚太地区
  • 中东、非洲

第11章 全球寡核苷酸合成市场:竞争情形

  • 竞争模式
  • 市场定位/占有率分析
  • M&A分析

第12章 全球寡核苷酸合成市场:企业简介

  • Agilent Technologies Inc.
  • Danaher Corp.
  • General Electric Co.
  • GenScript Biotech Corp.
  • Kaneka Corp.
  • Merck KGaA
  • Nitto Denko Corp.
  • QIAGEN NV
  • Sarepta Therapeutics Inc.
  • Thermo Fisher Scientific Inc.等

第13章 全球寡核苷酸合成市场:重要考察

第14章 全球寡核苷酸合成市场:DataM

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目录
Product Code: DMPH2649

Market Overview

The global oligonucleotide synthesis market size was valued US$ XX billion in 2020 and is estimated to reach US$ XX billion by 2028, growing at a CAGR of XX % during the forecast period (2021-2028).

Oligonucleotide synthesis is the chemical synthesis of relatively short fragments of nucleic acids with defined chemical structure. The technique is extremely useful in current laboratory practice because it provides a rapid and inexpensive access to custom-made oligonucleotides of the desired sequence.

Market Dynamics

The global oligonucleotide synthesis market growth is driven by its extensive used for the selection and determination of DNA sequences (hybridization probes or affinity purification), gene construction, and site-directed mutagenesis.

Increasing research activities in the pharmaceutical and biotechnology sectors The increasing prevalence of chronic and life-threatening diseases has prompted pharmaceutical companies and research firms to focus on R&D activities for the development of effective therapeutics. As a result, advances in life sciences research is leading to an improved understanding of biological systems. The development of oligonucleotide synthesis technologies has helped pharmaceutical and biotechnology researchers with molecular-level development, design, and modification of biological systems. The increasing research activities in the pharmaceutical and biotechnology sectors will lead to the expansion of the global oligonucleotide synthesis market.

Increasing focus on new oligonucleotide therapies will drive the market growth Pharmaceutical and biotechnological companies are focusing on R&D of new oligonucleotide drugs due to the presence of the limited number of approved drugs. Oligonucleotides efficiently target disease-relevant proteins and genes that are inaccessible by small-molecule drugs and biologic drugs. Recent advances have helped overcome challenges associated with the administration, cellular uptake, biodistribution, and side effects of oligonucleotide therapies. Currently, many oligonucleotide therapeutics are in various stages of clinical trials for the treatment of many diseases, including viral infections, rare genetic disorders, neural and neuromuscular conditions, and cancers. The presence of these drugs and increase in R&D is expected to have a positive impact on the overall market growth.

Regulatory issues associated with oligonucleotide therapeutics is likely to hinder the market growth

However, regulatory issues associated with oligonucleotide therapeutics, diversity in oligonucleotide molecules, and challenges in effective oligonucleotide delivery may hamper the growth of the oligonucleotide synthesis market over the forecast period.

COVID-19 Impact Analysis

The global oligonucleotide synthesis market has received immense impetus from the COVID-19 pandemic, as stakeholders are increasingly searching for newer approaches towards diagnosing and curing patients affected by the COVID-19. Pioneering research and development is being undertaken by bioSynthesis, a leading vendor. It has doled out ready-to-use cocktail mixes such as the SARS-CoV-2 N1 Oligo Mix, the SARS-CoV-2 N2 Oligo Mix and the Human RNase P (RP) Oligo Mix respectively. Such breakthroughs are generating a level of optimism amongst healthcare providers and stimulating them to keep the anti-coronavirus battle raging., hence, expected to boost the market growth over the forecast period.

Segment Analysis

Synthesized oligonucleotides segment is expected to grow at the fastest CAGR during the forecast period (2021-2028)

Synthetic oligonucleotides in therapeutics for treating neurodegenerative diseases and cancer is anticipated to heighten market prospects. Synthetic oligonucleotides are most reliably produced using a solid synthesis approach. It allows oligonucleotides to be custom designed to produce specific genetic sequences. To obtain the desired oligonucleotide each building block, comprising on a nucleic acid is coupled sequentially to the growing chain until the desired product is achieved. Once complete the oligonucleotide chain is released from the solid support used for synthesis, deprotected and the final product purified.

It is also common to see synthetic oligonucleotides modified at the ribose sugar to form bridged nucleic acids or linked nucleic acids which is promising for antisense and silencing RNA applications, the process by which gene expression is negatively affected leading to sequence specific gene silencing. These bridged nucleic acids lead to the formation of constrained or inaccessible oligonucleotides which introduces additional stability to the molecule. The conformational inflexibility bridging the sugar moiety brings results in a gain in binding affinity of the oligonucleotide to complementary strands of RNA and DNA.

  • Oligonucleotide-based drugs: Oligonucleotide-based drugs, in particular antisense oligonucleotides, are part of a growing number of pharmaceutical and biotech programs progressing to treat a wide range of indications including cancer, cardiovascular, neurodegenerative, neuromuscular, and respiratory diseases, as well as other severe and rare diseases. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide covering all key aspects of this increasingly popular area of pharmacology and biotech and pharma research, from the basic science behind antisense oligonucleotides chemistry, toxicology, manufacturing, to safety assessments, the design of therapeutic protocols, to clinical experience. More than 200 unique oligonucleotide-based product candidates are currently being evaluated in various preclinical / clinical phases of development. In fact, more than 270 registered clinical trials focused on oligonucleotides, till 2019, it is worth noting that the maximum (34) number of trials were registered in 2019.
  • Probes : Probe is a small fragment of DNA or RNA used to detect the target DNA or RNA in the sample by molecular hybridization. They are also known as molecular markers. The length of the probe can vary (100 to 1000 bases), and probe nucleotides are complementary to the part of the target sequence. For the ease of detection, probes are labeled with radioactive isotopes or with fluorescent dyes or antibodies. Probes bind with the complementary bases of the target sequence and reveal the presence of the target DNA or RNA in the sample. There are two main methods of labelling probes: end labeling and nick translation. Probes are categorized into different types including DNA probes, RNA probes, cDNa probes and synthetic oligonucleotides probes, and they are prepared using different techniques.
  • Primers : Primer is a small stretch of DNA or RNA that serves as a starting point for DNA replication. This acts as a starting point for DNA synthesis. Primer anneals with the complementary bases of the DNA strands. They are generally not labeled. The target sequence is flanked by two primers known as forward primer and reverse primer. Specificity and complementarity are the primary factors in the designing of primers. Secondary structures should also be avoided.

Hospitals are expected to dominate the global oligonucleotide synthesis market during the forecast period

The significant number of inpatient and outpatient visits in hospitals coupled with the high requirement of oligonucleotide drugs to cater to the demand from the vast patient pool suffering from diseases such as Duchenne muscular dystrophy, spinal muscular atrophy, and hepatic veno-occlusive disease, is driving the market growth in the segment.

However, in the developing countries of Asia-pacific and Africa, the hospital infrastructure is still underdeveloped which is hampering the market in the forecast period. For instance, in India the number of hospital beds per 1,000 population is less than 1, which is well below the World Health Organization (WHO) average of around 2.7 and the Organization for Economic Co-operation and Development (OECD) average of over 5. While some of the recent investments in the hospital sector are as follows, the value of merger and acquisition (M&A) deals across hospitals jumped by a record. This factor will drive the growth of the market in the forecast period.

Geographical Analysis

North America region holds the largest market share global oligonucleotide synthesis market

North America region is dominating the global oligonucleotide synthesis market accounted for the largest market share in 2020, due to the increasing R&D activities and the growing number of oligonucleotide-based drugs/therapies being approved by the FDA. The presence of innovators and key players in the U.S. has resulted in higher penetration of products in the market. Furthermore, the strong foothold of North America in genomics, proteomics, oncology, diagnostic screening, and drug discovery has significantly contributed to maintaining its large share. Government and private entities are investing in the development of academic and research infrastructure in North America. Moreover, collaboration among major players and universities for the development of novel approaches to curing chronic conditions through genetic medicine is expected to contribute to the growth of the market in the forecast period.

Competitive Landscape

The oligonucleotide synthesis market is moderately competitive with presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include Agilent Technologies Inc., Danaher Corp., General Electric Co., GenScript Biotech Corp., Kaneka Corp., Merck KGaA, Nitto Denko Corp., QIAGEN NV, Sarepta Therapeutics Inc., and Thermo Fisher Scientific Inc. among others. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the oligonucleotide synthesis market globally.

Oligonucleotide Synthesis Market Key Companies to Watch

Thermo Fisher Scientific Inc.

Overview: Founded in 2006 and is headquartered at Waltham, Massachusetts, the U.S.; Thermo Fisher Scientific Inc. is engaged in providing analytical instruments, equipment, reagents and consumables, software and services for research, manufacturing, analysis, discovery, and diagnostics services under the brands Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, and Unity Lab Services worldwide. The company operates through four business segments, namely, Analytical Instruments, Life Sciences Solutions, Laboratory Products and Services, and Specialty Services. The company provides oligonucleotide products through Invitrogen, under life Sciences solutions business segment.

With its subsidiaries and strong network of distribution, the company has its presence across North America, Europe, Asia Pacific, Latin America, and Middle East & Africa.

Product Portfolio: The Company's portfolio comprised its lead Iodine-Water-Pyridine-Tetrahydrofuran Oxidizer Solution (0.02 M), Trifluoroacetic Acid (TFA) Neat Liquid, in addition to Trichloroacetic Acid Dichloromethane, Deblocking Solution targeting high-performance reagents begin with raw materials that must conform to strict specifications.

Key Development: In February 2019, Thermo Fisher Scientific entered into an agreement with BioNTech (Germany). Under the terms of this agreement, BioNTech's messenger RNA (mRNA) manufacturing platform will be supported by Thermo Fisher through the supply of nucleotides, enzymes, and other critical raw materials.

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The global oligonucleotide synthesis market report would provide an access to an approx. 63 market data table, 53 figures and 230 pages.

Target Audience

  • Service Providers/ Buyers
  • Industry Investors/Investment Bankers
  • Education & Research Institutes
  • Research Professionals
  • Emerging Companies
  • Manufacturers

Market Segmentation

Global Oligonucleotide Synthesis Market - By Product

  • Reagents
  • Equipment
  • Synthesized Oligonucleotides

Oligonucleotide-based drugs

Primers

Probes

Large-scale synthesized oligonucleotides

Others

Global Oligonucleotide Synthesis Market - By Application

  • Research

PCR

QPCR

Sequencing

Gene Synthesis

Others

  • Diagnostics
  • Therapeutics

DNA & Antisense Oligonucleotide-based Therapies

RNAi Oligonucleotide-based Therapies

CpG Oligonucleotide-based Therapies

Global Oligonucleotide Synthesis Market - By End-User

  • Hospitals
  • Academic & Research Institutes
  • Pharmaceutical & Biotechnology Companies
  • Diagnostic Laboratories

Global Oligonucleotide Synthesis Market - By Region

  • North America
  • South America
  • Europe
  • Asia
  • Middle East & Africa

Table of Contents

1. Global Oligonucleotide Synthesis Market Methodology and Scope

  • 1.1. Research Methodology
  • 1.2. Research Objective and Scope of the Report

2. Global Oligonucleotide Synthesis Market - Market Definition and Overview

3. Global Oligonucleotide Synthesis Market - Executive Summary

  • 3.1. Market Snippet by Product
  • 3.2. Market snippet by Application
  • 3.3. Market snippet by End-User
  • 3.4. Market Snippet by Region

4. Global Oligonucleotide Synthesis Market - Market Dynamics

  • 4.1. Market Impacting Factors
    • 4.1.1. Drivers
      • 4.1.1.1. Increasing research activities in the pharmaceutical and biotechnology sectors
      • 4.1.1.2. Increasing focus on oligonucleotide therapies
      • 4.1.1.3. XX
    • 4.1.2. Restraints:
      • 4.1.2.1. Regulatory issues associated with oligonucleotide therapeutics,
      • 4.1.2.2. Challenges in effective oligonucleotide delivery drugs
      • 4.1.2.3. XX
    • 4.1.3. Opportunity
    • 4.1.4. Impact Analysis

5. Global Oligonucleotide Synthesis Market - Industry Analysis

  • 5.1. Porter's Five Forces Analysis
  • 5.2. Supply Chain Analysis
  • 5.3. Clinical Trials
  • 5.4. Pricing Analysis
  • 5.5. Regulatory Analysis
  • 5.6. Reimbursement Analysis
  • 5.7. Unmet Needs

6. Global Oligonucleotide Synthesis Market - COVID-19 Analysis

  • 6.1. Analysis of Covid-19 on the Market
    • 6.1.1. Before COVID-19 Market Scenario
    • 6.1.2. Present COVID-19 Market Scenario
    • 6.1.3. After COVID-19 or Future Scenario
  • 6.2. Pricing Dynamics Amid Covid-19
  • 6.3. Demand-Supply Spectrum
  • 6.4. Government Initiatives Related to the Market During Pandemic
  • 6.5. Manufacturers Strategic Initiatives
  • 6.6. Conclusion

7. Global Oligonucleotide Synthesis Market - By Product

  • 7.1. Introduction
    • 7.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product Segment
    • 7.1.2. Market Attractiveness Index, By Product Segment
  • 7.2. Reagents *
    • 7.2.1. Introduction
    • 7.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
  • 7.3. Equipment
  • 7.4. Synthesized Oligonucleotides
    • 7.4.1. Oligonucleotide-based drugs
    • 7.4.2. Primers
    • 7.4.3. Probes
    • 7.4.4. Large-scale synthesized oligonucleotides
    • 7.4.5. Others

8. Global Oligonucleotide Synthesis Market - By Application

  • 8.1. Introduction
    • 8.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 8.1.2. Market Attractiveness Index, By Application Segment
  • 8.2. Research *
    • 8.2.1. Introduction
    • 8.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
    • 8.2.3. PCR
    • 8.2.4. QPCR
    • 8.2.5. Sequencing
    • 8.2.6. Gene Synthesis
    • 8.2.7. Other
  • 8.3. Diagnostics
  • 8.4. Therapeutics
    • 8.4.1. DNA & Antisense Oligonucleotide-based Therapies
    • 8.4.2. RNAi Oligonucleotide-based Therapies
    • 8.4.3. CpG Oligonucleotide-based Therapies

9. Global Oligonucleotide Synthesis Market - By End-User

  • 9.1. Introduction
    • 9.1.1. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-User
    • 9.1.2. Market Attractiveness Index, By End-User Segment
  • 9.2. Hospitals *
    • 9.2.1. Introduction
    • 9.2.2. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-2028
  • 9.3. Academic & Research Institutes
  • 9.4. Pharmaceutical & Biotechnology Companies
  • 9.5. Diagnostic Laboratories

10. Global Oligonucleotide Synthesis Market - By Region

  • 10.1. Introduction
    • 10.1.1. Market Size Analysis, US$ Million, 2018-2028 and Y-o-Y Growth Analysis (%), 2020-202, By Region
    • 10.1.2. Market Attractiveness Index, By Region
  • 10.2. North America
    • 10.2.1. Introduction
    • 10.2.2. Key Region-Specific Dynamics
    • 10.2.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
    • 10.2.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 10.2.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-User
    • 10.2.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.2.6.1. U.S.
      • 10.2.6.2. Canada
      • 10.2.6.3. Mexico
  • 10.3. Europe
    • 10.3.1. Introduction
    • 10.3.2. Key Region-Specific Dynamics
    • 10.3.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
    • 10.3.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 10.3.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-User
    • 10.3.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.3.6.1. Germany
      • 10.3.6.2. U.K.
      • 10.3.6.3. France
      • 10.3.6.4. Italy
      • 10.3.6.5. Spain
      • 10.3.6.6. Rest of Europe
  • 10.4. South America
    • 10.4.1. Introduction
    • 10.4.2. Key Region-Specific Dynamics
    • 10.4.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
    • 10.4.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 10.4.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-User
    • 10.4.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.4.6.1. Brazil
      • 10.4.6.2. Argentina
      • 10.4.6.3. Rest of South America
  • 10.5. Asia Pacific
    • 10.5.1. Introduction
    • 10.5.2. Key Region-Specific Dynamics
    • 10.5.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
    • 10.5.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 10.5.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-User
    • 10.5.6. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Country
      • 10.5.6.1. China
      • 10.5.6.2. India
      • 10.5.6.3. Japan
      • 10.5.6.4. Australia
      • 10.5.6.5. Rest of Asia Pacific
  • 10.6. Middle East and Africa
    • 10.6.1. Introduction
    • 10.6.2. Key Region-Specific Dynamics
    • 10.6.3. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Product
    • 10.6.4. Market Size Analysis, and Y-o-Y Growth Analysis (%), By Application
    • 10.6.5. Market Size Analysis, and Y-o-Y Growth Analysis (%), By End-User

11. Global Oligonucleotide Synthesis Market - Competitive Landscape

  • 11.1. Key Developments and Strategies
  • 11.2. Company Share Analysis
  • 11.3. Product Benchmarking
  • 11.4. List of key companies to watch
  • 11.5. List of the company with disruptive technology
  • 11.6. List of start-up companies

12. Global Oligonucleotide Synthesis Market- Company Profiles

  • 12.1. Agilent Technologies Inc.*
    • 12.1.1. Company Overview
    • 12.1.2. Product Portfolio and Description
    • 12.1.3. Key Highlights
    • 12.1.4. Financial Overview
  • 12.2. Danaher Corp.
  • 12.3. General Electric Co.
  • 12.4. GenScript Biotech Corp.
  • 12.5. Kaneka Corp.
  • 12.6. Merck KGaA
  • 12.7. Nitto Denko Corp.
  • 12.8. QIAGEN NV
  • 12.9. Sarepta Therapeutics Inc.
  • 12.10. Thermo Fisher Scientific Inc.

LIST NOT EXHAUSTIVE

13. Global Oligonucleotide Synthesis Market - DataM

  • 13.1. Appendix
  • 13.2. About Us and Services
  • 13.3. Contact Us