Abstract
OVERVIEW
Gene sequencing technology, initially semi-automated in the 1980' s, is rapidly
advancing to support cutting-edge exploration into disease diagnostics and
therapeutic intervention. With the ability to sequence millions of DNA
segments in a single run and identify diagnostic markers for multiple species
in a sample - without cloning or PCR amplification - sequencing technologies
are on the cusp of a new generation. Coined “third gen,” the race
for genomics tool suppliers to develop faster more cost-effective sequencing
instruments is fueled by a global mission to reduce the cost of sequencing the
human genome to under $1,000 US dollars. Cheaper and faster are the keywords
in sequencing innovation. But new technologies don' t necessarily render old
ones obsolete, as the early sequencing techniques (e.g., Sanger) still present
the best solution for specific applications.
Balancing innovation with the realities of how quickly labs will adopt new
platforms is the challenge for next generation sequencing (NGS) product
suppliers. New technologies create excitement, but installing and learning how
to incorporate new systems into ongoing research requires a desire (and
commitment) from the lab. BioInformatics LLC' s upcoming report, The Global
Outlook for Next Generation Sequencing: Usage, Preferences and Budgets, was
designed to help NGS product suppliers move forward into uncharted territory
in a strategic way so as to optimize solutions that are relevant to the
research and realistic for laboratories to adopt.
This worldwide study of the academic and pharma/biotech sectors provides a
market analysis of NGS and an assessment of the brand equity and brand
positioning of companies providing NGS instrumentation and consumables. To
better understand the current market for NGS technologies, the report includes
an in-depth exploration of NGS technologies currently deployed, workflow and
types of applications. To assist with competitive benchmarking, study
respondents are asked to compare brands across multiple criteria (e.g.
accuracy of reads, ease of use, innovation of technology, turnaround
time/experiment time etc.) and rank them on value for price paid,
satisfaction and gaps in product offerings. Understanding current usage and
brand preferences help to identify must-have features and unmet needs, which
illuminates gaps in individual vendor offerings and opportunities in the
market as a whole.
For future planning purposes, the report includes average lab budgets for NGS
and predicted growth in lab budgets through 2012. Purchasing drivers are
delineated, and upcoming plans, criteria and funding for purchases are
explored. In addition, the report provides direction from the scientists as
to where the market is headed and the impact of new markets such as
diagnostics and personal genomics.
The Global Outlook for Next Generation Sequencing: Usage, Preferences and
Budgets was designed for next generation sequencing product suppliers who are
navigating a technology frontier that has captured the imagination of
researchers, healthcare providers and entrepreneurs. This report will help
suppliers allocate resources to new applications & markets and to optimize
current products by making them more responsive to scientists who are already
engaged in the next generation of whole genome sequencing.
THIS REPORT WILL HELP YOU TO:
This study will explore market analytics:
- Adoption projections for users of NGS technology
- Technology drivers
- Market share by brand of NGS platform
- Sources of funding
- Percent of annual budgets spent on NGS
- Primary research application(s)
- Unmet current and future NGS technology needs
- ...and more!
This study will also explore brand analytics:
- Brand awareness of NGS instrument brands
- Brand comparisons
- Purchasing drivers
- Satisfaction levels with NGS platform attributes
- Willingness to recommend
- Most popular NGS provider
- ...and more!
REPORT HIGHLIGHTS
About the Respondents
- Type of lab
- Use of next generation sequencing
- Motivations for using next generation sequencing
Awareness and Use
- Unaided, top-of-mind awareness: next generation sequencing providers and
platforms
- Aided awareness/consideration of use: next generation sequencing providers
and platforms
- “Best in class” by category:
- Accuracy of reads
- Assay cost
- Cost of platform
- Ease of use
- Innovation of sequencing technology
- Turnaround time/Experiment time
- Next generation sequencing instruments owned, instruments used, and
primary instrument used
- Next generation sequencing instrument purchases planned within the next 2
years
Customer Satisfaction
- Satisfaction by instrument:
- Amount of DNA/RNA needed per experiment
- Appropriate for my application
- Automation capabilities
- Available software analysis tools
- Cost per base
- Ease of use
- Instrument reliability
- Instrument size
- Number of reads
- Preparation time (prep and pre-amp)
- Procedural time (total time)
- Read length
- Reproducibility/accuracy
- Sample preparation requirements
- Sequencing data quality
- Size of data files produced
- Instrument cost
- Yield
- Overall satisfaction by top instrument platforms
- Satisfaction by supplier:
- Brand name/company reputation
- Citations in peer-reviewed publications
- Customer service
- Customer training (in use of the instrument)
- Financing
- Level of technological innovation
- Maintenance/service warranty
- Promotions/discounts
- Sales reps
- Technical support
- Overall satisfaction by supplier
- Value rating by supplier
- Likelihood of recommendation by top suppliers
- Perceived similarities and differences in sequencing platforms with
respect to:
- Innovation
- Accuracy of reads
- Ease of use
- Turn around time/experiment time
Use and Applications of Next Generation Sequencing
- “Big picture” focus of next generation sequencing research
- Primary application for next generation sequencing platforms
- Location (current/planned) of next generation sequencing workflow
- Next generation sequencing workflow:
- Time spent, level of difficulty by step
- Bottlenecks
- How suppliers can address bottlenecks (qualitative)
- Maximum read length typically needed
- Maximum yield typically needed
Purchasing a Next Generation Sequencing Platform
- Respondents' role in purchasing
- Sources of funding
- Percent of funding used for next generation sequencing instrumentation
- Most important platform features when purchasing a new next generation
sequencing instrument
- Most important provider attributes/services when purchasing a new next
generation sequencing instrument
Lab Budgets for Next Generation Sequencing
- Total budget for FY2010, FY2011, FY2012
- Percent of total budget spent on next generation sequencing
- Next generation sequencing budget spending
Consumables and Techniques Supporting Next Generation Sequencing
- Sample management
- Sample prep
- Sample selection
- Pre-sequencing amplification
- Kits and consumables used/planned to use
- Satisfaction with kits and consumables (qualitative)
- Brand preferences: kits and consumables
- Brand preferences explained (qualitative)
- Techniques used in conjunction with next generation sequencing (PCR,
Sequence Capture, Gel/Blotting, Misc.)
Future of Next Generation Sequencing
- Currently limiting aspects of next generation sequencing
- “Most significant improvement” to next generation sequencing
workflow
- Degree of “most significant improvement” (qualitative)
Learning About Next Generation Sequencing Technology and New Products
- Sources of information for next generation sequencing product offerings
- Respondent nominations for:
- Best Next Generation Sequencing Conference
- Best Scientific Journal
- Best Reference Website
- Best Research Center of Excellence
- Best Thought or Knowledge Leader in the Field
- Total researchers working in respondent labs/groups
Qualitative
- If cost were no object, would you get your own genome sequenced? Why or
why not?
KEY FINDINGS
Most Significant Improvement to Your
Next Generation Sequencing Workflow
©2011 BioInformatics, LLC
Most Informative Sources of Next Generation
Sequencing Product Information
©2011 BioInformatics, LLC
WHY CHOOSE OUR REPORTS?
Sources of Independent, Unbiased Research
Unlike reports from other firms that are based on an analyst' s subjective
summary of information from publicly available sources, our reports are based
on the results of detailed surveys of hundreds - even thousands - of
scientific and medical professionals who buy your products.
Developed by a Team of Experts
Our questionnaires are developed by a multi-disciplinary team of scientists,
industry veterans and market research experts with years of experience. These
professionals understand that survey questions need to be asked in a way that
ensures the answers will directly address the business challenges you face.
Once the survey data is collected, this same team creates a unique report that
presents the reader with a thorough understanding of the topic and the
scientific and business implications of the results based on sophisticated
statistical analytics.
Custom Analysis & Research Available
If you' d like to delve deeper into the data from a study, we can always
perform custom cross-tabulations or other analysis on your behalf. We can even
pose follow-up questions to respondents who answered in a particular way or
conduct a custom study to extend your knowledge.
Carefully Selected Survey Participants
When others promote results from their online surveys, they fail to mention
the uncontrolled nature of their broadcast email invitations. To provide you
with the most valid and accurate results possible, the respondents to our
surveys are members of our unique online panel - The Science Advisory Board® -
which consists of more than 66,000 verified life science and biomedical
professionals who have agreed to take part in our surveys, focus groups and
other market research activities. These respondents are carefully selected
based on their professional qualifications, market segments and geographic
regions - we can even select them based on the products they use and their
preferred suppliers.
ABOUT BIOINFORMATICS LLC
Since our inception in 1994, BioInformatics has provided critical market
intelligence to leading companies serving the life science, medical device and
pharmaceutical industries. We support clients across the entire market
spectrum - from scientific research to diagnostics and therapeutics -
providing high-level management with market insights from gene to drug.
Our multi-disciplinary team of scientific experts and business analysts
creates value for our clients by combining extensive industry knowledge and
experience. We offer a variety of products and services that enable executives
to see themselves, their market and their competitors through the eyes of the
most important information source of all - customers. We can precisely meet
the needs of our clients through the most appropriate mix of research
methodologies, including:
- Online Surveys
- Online Focus Groups
- Telephone Interviews
Table of Contents
Section 1: Presentation of Key Findings
- Introduction
- The Evolution of Next Generation Technology
- Factors Affecting Next Generation Sequencing Platform Sales
- Next Generation Technology Market Outlook
- Next Generation Sequencing Workflow Analysis
- Next Generation Sequencing Provider Profiles
- Illumina/Solexa Sequencing
- Life Technologies: SOLiD Sequencing and Ion Torrent
- Roche/454 Sequencing
- Demographics of Study Participants
Section 2: Methodology and Questionnaire
- Questionnaire Overview
- Questionnaire Design
- Analytical Techniques
- Demographics
- Questionnaire
Section 3: Appendices
- Appendix A: Insights and Perspectives
- Appendix B: Other Publications
- Appendix C: About BioInformatics LLC
- Appendix D: Our Valued Clients
