基因发现试药市场

Abstract

The area of gene expression reagents is one of the newest and most important sectors of pharmaceutical and bioscience research and development. The term gene expression reagents refers to chemicals that are used in gene expression experiments that are performed to determine whether a particular gene is expressed-i.e., present-and in some cases at what levels, in a biological sample. The purpose of this TriMark Publications report is to describe the specific segments of the global gene expression reagents market. Within this area, the study covers those segments that are highly active in terms of innovation and growth. Specifically, this review examines the markets for gene expression reagents and small lab equipment all the way up to highly automated platforms. Emphasis is on those companies that are actively developing and marketing gene expression reagents for genomics research in the academic sector and the pharmaceutical, bioscience industry. This study concentrates on the laboratory reagent market segment and the companion gene expression reagents sector in the U.S. and around the world that use materials for genetic research. Particular attention is paid to those areas of the gene expression reagents sector that are showing the greatest growth or the most innovation.

The report attempts to answer the following questions:

• What companies are the key players?
• What is the market for gene express reagents?
• What are the opportunities in gene expression reagents markets?
• What are the developing trends?
• Where are the new market growth areas?
• What are the most favored technology platforms?
• Where are the gene expression reagent technologies taking researchers?
• How are gene expression reagent technologies blending with more established laboratory procedures?
• What are the business trends in the industry?

The study surveys some of the leading companies known to be marketing, manufacturing or developing products for the gene expression reagents market for those sectors covered here. Each company is discussed in depth with a section on the history of the company, the product line, business and marketing analysis, and a subjective commentary of the position of the company in its market.

The benefits of this report are:

• In-depth analysis of the major sectors of the gene expression reagent sectors, their size, growth rates and major drivers.
• Presentation of some of the emerging technology platforms, elucidating the potential areas that could gain traction in this market.
• Analysis of the partnerships and alliances the various key sector players have forged, as well as describing financings of these market participants, giving insight into potential market collaborations.
• Examination of new technology platforms that seek to dominate this new market, and to identify lead positions and potential future growth areas.
• An overview of the current state of gene expression assays used in drug development and the numerous opportunities that exist to increase the quality of genetic sequences evaluated.
• A profile of the gene expression customer and an analysis of factors influencing the adoption of specific gene exploration technology.
• A five-year projection of spending on new equipment and reagents.
• Impact of commercial gene reagents on genetic R&D.

Table of Contents

1. Overview

• 1.1Objectives of the Report
• 1.2Methodology
• 1.3Scope of the Report
• 1.4Executive Summary

2. Gene Expression

• 2.1The Genomics Revolution
• 2.2Basic Principles of Gene Expression
  • 2.3.1Quantitative Real-Time PCR (qRT-PCR)
  • 2.3.2PCR Labeling Chemistries
  • 2.3.3TaqMan® Probes
  • 2.3.4SYBR® Green
• 2.4Microarray Technology
• 2.5Microarray Target Preparation and Hybridization
• 2.6RNA Sample Preparation and Assessment

3. Gene Expression Reagents

• 3.1Kit Format vs. Home-Brew Assays
• 3.2Whole Product Solutions
• 3.3Emerging Technologies

4. Market Environment

• 4.1Institutional and Government Budgeting
• 4.2Worldwide Investment in Genomics Technologies and Research
• 4.3Industry Consolidation and Acquisitions

5. Market Drivers

• 5.1Improved Assay Performance
• 5.2Cost Effective Systems
• 5.3Automation
• 5.4Bioinformatics Solutions

6. Worldwide Market for Gene Expression Reagents

• 6.1Life Science Research
• 6.2Drug Discovery and Development, Molecular Diagnostics
• 6.3Commercial Production
• 6.4Gene Expression Market Size
  • 6.4.1Real-Time PCR Revenue
  • 6.4.2Commercial Microarray Revenue
  • 6.4.3RNA Sample Preparation Revenue
• 6.5Gene Expression Reagent Market by Region
• 6.6Users of Gene Expression Products
  • 6.6.1Core Laboratories
  • 6.6.2Consortia
  • 6.6.3Pharmaceutical and Biotechnology Companies
• 6.7Affiliation
• 6.8Job Function and Decision Makers

7. Key Applications

• 7.1BioMarker Identification and Pharmacogenomics
• 7.2Toxicogenomics
• 7.3Molecular Diagnostics

8. Vendor and Product Selection

• 8.1Product Adoption
• 8.2Drivers for Product Switching

9. Leading Vendors

10. Marketing Strategies

• 10.1e-Marketing and e-Commerce
• 10.2Catalog
• 10.3On-Site Cabinet Programs

11. Pricing Strategies

• 11.1Price Elasticity
• 11.2Strategies

12. Distribution Channels

13. Competitive Situation

14. Opportunities

15. Market Strategy Profiles, Leading and Selected Vendors

• 15.1Applied Biosystems
  • 15.1.1Applera Corporation-Corporate History and Structure
  • 15.1.2Molecular Biology Technology and Products
  • 15.1.3Acquisitions, Partnerships and Collaborations, 2006
  • 15.1.4Product Portfolio Summary
  • 15.1.5Real-Time PCR/Genomics Products and Consumables
  • 15.1.6Real-Time PCR/Genomics New Product Introductions, 2006
  • 15.1.7End-Users
  • 15.1.8Distribution Channels
  • 15.1.9Competition-Gene Expression Products
  • 15.1.10Competitive Analysis
  • 15.1.11Business Model
• 15.2Affymetrix
  • 15.2.1Corporate History and Structure
  • 15.2.2Technology
  • 15.2.3Partnerships and Collaborations
  • 15.2.4Product Portfolio Summary
  • 15.2.5Complementary Services
  • 15.2.6New Product Introductions
  • 15.2.7End-Users
  • 15.2.8Distribution Channels
  • 15.2.9Competition
  • 15.2.10Competitive Analysis
  • 15.2.11Business Model
• 15.3Invitrogen
  • 15.3.1Corporate History and Structure
  • 15.3.2Technology
  • 15.3.3Acquisitions
  • 15.3.4Partnerships and Collaborations
  • 15.3.5Product Profile Summary
  • 15.3.6Gene Expression Product Portfolio
  • 15.3.7New Product Introductions
  • 15.3.8End-Users
  • 15.3.9Distribution Channels
  • 15.3.10Competition
  • 15.3.11Competitive Analysis
  • 15.3.12Business Model
• 15.4Qiagen
  • 15.4.1Corporate History and Structure
  • 15.4.2Technology
  • 15.4.3Acquisitions, Partnerships and Collaborations
  • 15.4.4Collaborations and Partnerships
  • 15.4.5Product Portfolio Summary
  • 15.4.6Complementary Services
  • 15.4.7New Product Introductions
  • 15.4.8End-Users
  • 15.4.9Distribution Channels
  • 15.4.10Competition
  • 15.4.11Competitive Analysis
  • 15.4.12Business Model
• 15.5GE Healthcare (Formerly Amersham Biosciences)
  • 15.5.1Corporate History and Structure
  • 15.5.2Technology
  • 15.5.3Product Portfolio Summary
  • 15.5.4Complementary Services
  • 15.5.5Genomics New Product Introductions
  • 15.5.6Amersham Biosciences End-Users
  • 15.5.7Distribution Channels
  • 15.5.8Competition
  • 15.5.9Competitive Analysis
  • 15.5.10Business Model
• 15.6Stratagene
  • 15.6.1Corporate History and Structure
  • 15.6.2Technology
  • 15.6.3Acquisitions, Collaborations, Alliances and Partnerships
  • 15.6.4Product Portfolio Summary-Research Products Division
  • 15.6.5New Product Introductions
  • 15.6.6Complementary Services
  • 15.6.7End-Users
  • 15.6.8Distribution Channels
  • 15.6.9Competition
  • 15.6.10Competitive Analysis
  • 15.6.11Business Model

Appendix I: Leading Vendor' s Gene Expression Products

Appendix II: Gene Expression Product Groups

Appendix III: Companies Offering Gene Expression Products

LIST OF FIGURES

• Figure 2.1: Gene Expression Process
• Figure 2.2: qRT-PCR Workflow
• Figure 2.3: Microarray Workflow
• Figure 6.1: Gene Expression Market by Region
• Figure 6.2: Researchers Using Gene Expression Technologies Worldwide, 2005
• Figure 6.3: Distribution of Laboratory Workers by Organization in North America
• Figure 6.4: Laboratory Job Function
• Figure 6.5: Product Selection and Purchasing Decision Makers

LIST OF TABLES

• Table 5.1: Microarray Analysis Cost per Sample
• Table 5.2: Cost of qRT-PCR Research Reagents and Systems
• Table 6.1: Five-Year Forecast-Gene Expression Reagents, Instruments
• Table 6.2: RNA Sample Preparation Revenue
• Table 6.3: Forecasted Annual Revenue-qRT-PCR, 2005-2010
• Table 6.4: Forecasted Annual Revenue-Commercial Microarrays, Reagents, Instruments, 2005-2010
• Table 6.5: Forecasted Annual Revenue-Gene Expression Reagents, Instruments, 2005-2010
• Table 6.6: Forecasted Annual Revenue-RNA Sample Preparation, 2005-2010
• Table 6.7: Projected Revenue Growth of Microarrays and Related Products
• Table 6.8: Major Players' Distribution of Revenue by Region, 2005
• Table 6.9: Decision Makers Profile
• Table 9.1: Major Vendors-Gene Expression Reagents and RNA Sample Preparation
• Table 9.2: Vendors' Key Statistics, 2005
• Table 9.3: Vendors' Technology and Products
• Table 11.1: RNA Sample Preparation-Vendors Prices
• Table 11.2: qPCR Kits-Vendor' s Prices
• Table 11.3: Reverse Transcriptase-Vendor' s Prices
• Table 12.1: Distribution Channels
• Table 15.1: Applied Biosystems Revenue, 2005
• Table 15.2: Affymetrix Revenue, 2005
• Table 15.3: Invitrogen Revenue, 2005
• Table 15.4: Qiagen Revenue, 2005
• Table 15.5: GE Healthcare Revenue, 2005
• Table 15.6: Stratagene Revenue, 2005